The Wu Sisters are three of the minor antagonists in Kung Fu Panda: The Game.
In Secrets of the Masters
The leader of the Wu sisters, Su Wu, was locked away until her sisters, Wing Wu and Wan Wu, freed her from her prison. They escaped to their volcano fortress and soon devised plans to unite the most dangerous gangs to establish a criminal empire and take over China. Their plan was stopped by Rhino, Ox and Croc, who had worked together to defeat the leopard sisters.
Kung Fu Panda: The Video Game
Po ended up stumbling into their base camp when fleeing with the Dragon Scroll. When he runs into them and asks them for directions, they think he is spying on their camp and attack him. Po manages to defeat them and claims a map that will direct him back to the Jade Palace.
In Legendary Warriors
The Wu sisters return and attack the players while Tai Lung targeted Master Crane. They ended up defeated by the players.