Wes Mantooth is Ron Burgundy's chief rival, half-brother, and the lead anchor of KQHS Channel 9 Evening News Team, as well as the main antagonist in the movie Anchorman: The Legend of Ron Burgundy, and a cameo in Anchorman 2: The Legend Continues.
He is portrayed by the actor Vince Vaughn.
It is revealed early on that Mantooth is extremely sensitive about insults directed towards his mother, Dorothy Mantooth, whom he regards as a "saint".
Mantooth is consistently irritated by his being second in the ratings, causing him and his news team to ultimately initiate an anchorman battle against Burgundy and three other news teams in a street brawl using a knife.
The anchorman battle was interrupted and forcing everyone to ditch the fight. Later in the movie he pulls Burgundy from a ladder out of the bear pit, explaining that while he hates him he nonetheless respects him as a journalist.
- The character is loosely based on the CBC news anchor Peter Mansbridge.