Werewolves or The Omega Werewolves are portrayed as Hostile Species recruited by Phantom Werewolf are one of the main villains from the season 3 of Martin Mystery: Harrier and scarier.
When Martin Mystery got MOM's bad side and ends up cleaning monster facility of Block-C, he stumbles onto a seemingly empty cage which turns out to be the cage of Phantom Werewolf, a dangerous werewolf with abilities to turn humans into werewolves and rendering itself invisible. It ambushes Martin, injuring him on his wrist with its claws before it is contained.
Martin is rather quickly changing and doing things which he normally wouldn't do such as hitting on attractive girls out of the blue, uncontrollable hunger, feral taste for meats, lousy body odors, drastic hair growths on his body, beastly locomotion etc. embarrassing himself in the process. Eventually Martin realizes he is changing but out of fear he decides to keep it for himself.
Meanwhile, Mysterious kidnapping of male varsity students had been going on for some time, but no one knows who is the culprit. Java and Diana decide to investigate. Their investigation lead them to Phantom Werewolf who flees upon being sighted. Diana and Java both go after the werewolf, only to discover Martin changed into one. Both now know Martin is a werewolf, but he is not the kidnapper. Fearing what he might do, Martin flees from Diana and Java to join Phantom Werewolf's pack. Then, MOM reported in, notifying the escape of Phantom Werewolf to Java and Diana, realizing Martin had been transformed through Diana's report. MOM is upset that no one reported to Martin incident sooner but Diana and Java assure her they will bring back Martin and capture Phantom Werewolf.
When Java and Diana finally find Martin in a cave (who dug an underground cage to prevent himself from going feral and prowl), the Phantom Werewolf (who is the one conducting series of kidnapping varsity students all along) arrives as Martin turns into a werewolf, the Phantom Werewolf calls his wolf pack to attack Martin, but Martin, helped by Diana and Java, fights the omega werewolves one by one by knocking them down, when Martin is at the mercy of the Omega Werewolves, but Java uses the whistles to force the Omega Werewolves to retreat in order to save his friend. Martin, helped by Diana and Java, manages to defeat the Phantom Werewolf and has succeeded to lock him in a cage. Martin is still a werewolf in the house drinks a hair growth serum instead of an antitode at the episode ends, much to Martin's anger.
- The Werewolves are based in a mythology of these creatures in a urban legend, they bite a human by using a curse on a infected human to make a human a werewolves.
- The Werewolves are inspired by the Werepoodles like Valerie from Kids Next Door. But in a predator wolf only.