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Viruses DM

The Viruses are anthropomorphic embodiments of disease (albeit in a family-friendly manner) and the main antagonists of the Dr. Mario series as well as the spin-off, Dr. Luigi - like many Mario villains they are comical in appearance and nature but are theoretically very dangerous opponents since they would presumably spread illness across the Nintendo universe if Mario (and later Luigi) didn't keep them at bay.

Due to Dr. Mario being a puzzle-based, simplistic, game the Viruses do not speak nor have much influence but they serve as enemies along the line of famous video-game enemies such as Space Invaders or (fittingly) the original Koopa Troopas, having little backstory but being set as enemies for the hero to defeat.

Much like real-world virsuses the only way to defeat these microscopic creatures was with advanced medicine, symbolised in-game by stacking colored pills ontop of one another to destroy the virus that has the same color as the pills around it.

           Mario Villains

Koopa Troop
Bowser | Bowser Jr. | Koopalings: (Larry Koopa | Morton Koopa Jr. | Wendy O. Koopa | Iggy Koopa | Roy Koopa | Lemmy Koopa | Ludwig Von Koopa) | King Boo (Luigi's Mansion) | Boos

8 Bit Club
Wart | Mouser | Tryclyde | Fryguy | Clawgrip | Birdo | Shy Guys

Secret Society of X-Nauts
Sir Grodus | Lord Crump | Shadow Sirens | Shadow Queen

Count Bleck's Minions
Count Bleck | Nastasia | O'Chunks | Mimi

Smithy Gang
Smithy | Exor | Mack | Bowyer | Yaridovich | Axem Rangers | Blade | Boomer | Count Down | Cloaker | Domino | Clerk | Manager | Director | Factory Chief

Kremlings
King K. Rool | Kremling Krew | Klump | Krusha | Krunch | Klubba

Other
Antasma | Army Dillo | Ashley | Bonechill | Brobot | Cackletta | Chuckolator | Cortez | Dark Star | Dimentio | Dino Piranha | Donkey Kong | Doopliss | Draggadon | Eely-Mouth | Elder Princess Shroob | Fawful | Gooper Blooper | Grubba | Kent C. Koopa | King Bob-omb | Necky | Wizpig | Kaptain Skurvy | MegaBug | King Kaliente | Mr. L | Nabbit | Petey Piranha | Peewee Piranha | Phantom of the Bwahpera | Rabbids | Rabbid Kong | Shroobs | Tatanga | Sunnycide | Squizzard | Viruses | Waluigi | Wario | Wracktail | Wingo |