|“||My name is Capitan Vincente De Santa.||„|
|~ Captain De Santa introducing himself|
|“||You come to my country, my poor, little country, and you think you can be friends with the President?||„|
|~ Vincente De Santa to John Marston|
|“||(John Marston: Who is this man we're looking for, the leader of the rebels?) Abraham Reyes? He is a traitor, a liar, a coward and a sinner. A hero who has done nothing. (John Marston: That's a nice image.) He is from a rich family. A man born in a golden cradle, who pretends to fight for the poor. He is taking advantage of the ignorant and the weak-minded. (John Marston: He must be telling the people something they want to hear.) Of course he is! All that bastard does is stand on a balcón giving speeches. It is easy to make promises you can never keep.||„|
|~ De Santa's negative opinion on Abraham Reyes|
Captain Vincente De Santa is a major antagonist in Red Dead Redemption. De Santa is the quaternary antagonist of the Nuevo Paraiso chapter.
He is Colonel Allende's right hand man who initially greets John with a warm reception just when John entered Mexico saying that he had been sent to track down Bill Williamson and Javier Escuella. De Santa has John do a few jobs for him in order to earn his trust. Unbeknownst to John, Allende was hiding Bill all along.