The U-Men believed that stealing mutant body parts and grafting them into their members would create the perfect being, Homo Perfectus, they encountered students at the Xavier Institute on several occasions. One being, Xorn had the special class outside and U-men were spotted, Basilisk blasted one and Beak bashed the U-man's skull in (After using a condom to save Dummy's life). Meanwhile Xorn was spotted by Angel Salvatore to have destroyed a car with U-men presumably inside. On another occasion, the Omega Gang, lead by Kid Omega crashed into a U-men base, during a surgical transfer of body parts, killing the half dozen members.
The U-Men appear as the initial antagonists of Marvel Anime: X-Men. Here, they are portrayed as a human supremacist group led by Sublime (but backed by Mastermind of the Inner Circle) who are trying to harvest mutant body parts/powers similar to their comic book counterparts. One notable member is Kick (voiced by Dave Wittenberg), who has a past with Wolverine.