Tlotoxl is the villain of the 1964 Doctor Who Story "The Aztecs".
Tlotoxl was the Aztec High Priest of Sacrifice in the 15th century. Barbara Wright posed as the reincarnation of Yetaxa. When she called off the human sacrifice of the first victim, Tlotoxl declared her a false god. He tried poisoning her with the help of Tonila to prove Barbara's mortality, but failed when Barbara offered them the drink. Tlotoxl offered Tonila the position of High Priest of Knowledge when the previous High Priest Autloc left for the wilderness. At the solar eclipse, Tlotoxl tried stabbing Barbara, but Ian Chesterton caught him. Ian and Barbara left for the TARDIS and Tlotoxl was offered the Perfect Victim as a sacrifice.