Titano first appeared in Superman #127 (February 1959). Originally named Toto, he was dubbed "one of the world's most intelligent apes". Rocketed into space, he and his ship were bombarded with radiation, which changed him into a giant ape with incredible strength and the ability to emit beams of Kryptonite radiation from his eyes. This made the ape a difficult menace for Superman to face.
Titano was originally a normal baby chimpanzee used in cruel scientific experiments for the U.S. government. This lab is headed by Dr. Thomas Moyers, an irresponsible man who caused the creation of Rampage, the super-strong alter-ego of Dr. Kitty Faulkner. This scientist is not associated with Moyer's Titano project. The chimpanzee gains his name from a mean-spirited joke by the other staffers.
A brief visit by Lois Lane to the government laboratories ended soon after Titano tried to escape his tormentors by leaping into Lane's arms. An accident caused the ape to gain super-strength and grow to enormous proportions. Attempting to kill Dr. Thomas Moyers, whom he saw as his tormentor, Titano was stopped by and engaged in a battle with Superman. The presence of Lane causes Titano to calm down, as he considered her a friend. Moyers used his equipment to reverse the transformation. The reversal is too much for the chimpanzee, who dies in Lane's arms. Lois later wrote the Daily Planet article "Tears for Titano" in honor of the animal.