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Thrax (Osmosis Jones)

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Full Name
Big Daddy Thrax, The Red Death
Osmosis Jones (2001)
Powers / Skills
Can use his coat to glide, skilled combatant, his red finger incinerates anything it touches.
Infiltration of men, women and children-alike.
To be recorded in the medical books as the deadliest virus by killing Frank DeTorre within two days (failed)
Type of Villain
Serial-Killer Virus, Child Murderer, Pyrotic Villain, Outright Villain, Complete Monster

…Yeah , I'm getting better as I go along, baby, but the problem is I never set a record. Until my man Frank that is. I'm gonna take him down in 48 hours! Get my own chapter in the medical books!
~ Thrax regarding his latest victim, Frank

Thrax is the main antagonist of the 2001 live-action/animated Warner Bros film Osmosis Jones. He is an extremely virulent, one-of-a-kind virus, whose goal in life is to kill all his targets faster than the previous one, to make sure that history would remember him as the deadliest virus known to man.

He was voiced by Laurence Fishburne who played Omar in Ride Along.

Role in the film

In the beginning of the movie, Thrax enters the body of Frank DeTorre, a widower without the slightest regard for hygiene and health, right after he eats an egg that had monkey saliva on it and then fell on a muddy floor. He then enters Frank City, a city inside Frank's body where all his body cells are living a life identical to that of humans. Thrax quickly takes control of the many gangs of bacteria present and plans to take advantage of Frank's poor health condition to operate undetected.

Osmosis Jones, one of Frank's white blood cells who acts as an pope, and a cardinal named Drix soon discover that something dangerous is going on, but the objectionable Mayor Phlegmmings dismisses their warnings, going as far as refusing to acknowledge Thrax as a serious threat when he can no longer ignore his existence. Jones infiltrates a meeting of Thrax and his thugs in a zit, attempting to get in on Thrax's plans but is eventually caught. Drix arrives to assist Ozzy and after a brief battle, the zit explodes, killing most of Thrax's gang and conceivably the virus himself but he turns out to have survived. Later on Thrax and his remaining thugs hide out in the toe nail. As Thrax prepares to get back on schedule, one of his gangsters suggest they incubate for a while as they are few in numbers. Angered, Thrax kills his remaining mobsters by impaling them with his deadly claw, quoting "Medical books aren't written about losers!" as he heads off to kill Frank on his own.

Thrax battling Ozzy on Shane's eye

Ozzy battles Thrax in Shane's eye

Jones and Drix are ordered to cease their investigations, but they eventually disobey and manage to track down Thrax. He had sneaked into the hypothalamus and stole a DNA bead, causing Frank's body temperature to increase without end and seriously threatening his life. Jones and Drix manage to pursue Thrax outside of Frank's body (who has been admitted in a hospital) and Jones engaged him into a fight to get back the DNA bead. 

Thrax eventually dies by falling into a bottle of rubbing alcohol, as he was about to enter the body of Frank's daughter and start a new chain, which causes him to dissolve and die once and for all. Frank is then saved in extremis and the cells inside him make him adapt into a healthier lifestyle.


Thrax is an ambitious, intelligent, lethal and sadistic virus cell. Throughout the film Thrax has proved to be especially cruel, violent and ruthless, a person who would kill anyone got in the way of his own sinister designs or even just for the fun of it. When he entered Frank's body he murdered two cells even though they weren't a threat and one of them actually surrendered. This cruelty also shows when he entered the hypothalamus and killed two scientists that were in his way.

Thrax has proven to be proud and had a high opinion of himself an example of this would be when confronted by the Germ Gangster, Thrax proclaims that "Ebola is a case of dandruff compared to me!" He has proven to be a serial killer which is another thing that he is very proud about of until he eventually turned it into a sport and tried to kill his new inhabitan, Frank, in less than 48 hours so he could be known as the deadliest virus known to man and get his own chapter in the medical books.

Thrax has shown to be a capable fighter and could easily hold his own against Osmosis Jones during their battle on Shane's eyelashes and when he could have easily killed him by using his claw he chose to use his chain to strangle him to death. However despite this Thrax has also proven to be very intelligent especially when it came to the human body as he was able to locate the hypothalamus and trick the entire city of Frank into believing he only had a common cold.

Furthermore Thrax has not also proven to be a killer but has shown to be quite brutal while doing so fighting off the germs and killing their leader by slicing his neck. He also attempted to strangle Osmosis Jones when he could've easily killed him. Thrax also uses out of date terms and sayings to describe people such as "cat", "baby" and "sounds like a gas."

Thrax also appears to have a fondness of the song "Fever" as he is constantly seen singing it throughout the film. Thrax also uses heat puns such as "think I'll turn up the heat in here" and "can you feel the heat Jones?"

Powers and Abilities

  • Oversized claw on his left hand that can destroy or alter any cell, melting inanimate cells (materials) and setting living (anthropomorphic) cells ablaze.
  • Gliding by using his coat as a delta wing.
  • Super-strength while rapping.
  • Leadership abilities among viruses and bacteria.
  • High knowledge of the human body.


Sounds like a gas, baby. Bring it on
~ Thrax to The Boss
Ebola? Let me tell you something about ebola, baby. Ebola is a case of DANDRUFF compared to me!
~ Thrax when the Boss mocks him as "thinking he's ebola"
This DNA bead came from a little girl in Riverside, California. Didn't like to wash her hands. Took me three whole weeks. And this one: nice woman in Detroit, Motown. Six days flat. Then there's this old man in Philly. I killed him in 72 hours. Yeah, I'm getting better as I go along, baby, but the problem is I never set a record! Until my man Frank, that is. I'm gonna take him down in 48 hours! Get my own chapter in the medical books!
~ Thrax talking to a group of germ thugs, explaining his wicked evil plan to break his record by killing Frank Detore in 48 hours
This cat was sick before I even got here
~ Thrax after escaping from Frank's memories
You know what, Jones? You want this chain so bad, Big Daddy Thrax is gonna let you have it! Looks good on ya, Jones! You wear it well! It's a shame you had to come this far from home just to die.
~ Thrax strangling Osmosis Jones with the chain
Can you feel the heat, Jones? *laughs* Too bad you won't be here to see me break my record when I take down Frank's pretty little girl.(Ozzy: She Ain't going down!) Huh? (Ozzy: You are!) WHAT?! NO!
~ Thrax's last words and Ozzy's response



  • Thrax's name comes from the real life disease Anthrax, though Thrax cannot be likened to one virus in particular, though the symptoms resemble an exceptionally violent version of Scarlet Fever.
  • Thrax is described as La Muerta Roja (Red Death), in reference to the Edgar Allen Poe story, Masque of the Red Death; however the symptoms of the disease in the story bare little resemblance to the symptoms caused by Thrax.
  • Thrax is implied to be the one who killed Frank's wife.
  • The song Thrax's hums throughout the movie is called "Fever".


Osmosis Jones - Thrax vs Ozzy02:58

Osmosis Jones - Thrax vs Ozzy

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