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Thrax (Osmosis Jones)

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Villain Overview
Careful, I'm contagious.
~ Thrax's first and most famous quote.

Thrax is the main antagonist of the 2001 live action/animated film by Warner Bros., Osmosis Jones.

He is an extremely virulent, contagious, and pestilential anthropomorphic virus and a disturbingly vicious, dangerous, and intimidating murderer, who strives to be remembered as the deadliest virus known to man.

He was voiced by Laurence Fishburne who also played Omar.

Role in the film

In the beginning of the story, Thrax enters the body of Frank DeTorre, a widower without the slightest regard for hygiene and health, when the latter eats an egg that was just spit by a monkey into a muddy floor. By doing so, he infiltrates Frank City, a huge metropolis inside Frank's body in which each of his body cells are living a life identical to that of humans, with white blood cells as cops and germs as criminals. Thrax casually murders the two witnesses of his arrival, and goes to the germs headquarters in Frank's armpit. There, he quickly takes control of the germs gangs by killing their leader; and plans to take advantage of Frank's poor health condition to operate undetected.

The titular primary protagonist is Osmosis "Ozzy" Jones, one of Frank's white blood cells who was demoted from the police after he activated the emergency evacuation (i.e. throwing up), to get rid of germs from polluted oysters, which was seen as "unnecessary force". He gets reluctantly teamed up with a rule abiding cold pill named Drix (Drixenol) to investigate on a throat inflammation (in fact Thrax's doing), and they discover that something far more dangerous is going on. However, the incompetent and election-obsessed Mayor Phlegmming, who is to blame for Frank's disastrous life-style, dismisses their warnings and states that this is nothing more than a common cold.

Jones uses his body-altering abilities to pass as a germ and infiltrates a meeting of Thrax and his thugs inside a zit, to get in on what is going on. There, he discovers about Thrax's plan to set a record with Frank's death. When Ozzy is caught, Drix barges him just as Thrax was about to incinerate him. After a brief battle, the zit is destroyed in the explosion of a medicine grenade, killing most of Thrax's gang and seemingly Thrax himself as well. Yet, the virus has survived and his hiding in a toenail with his remaining thugs. As Thrax prepares to get back on schedule, one of his gangsters suggest they incubate for a while as they are few in numbers. Angered, Thrax kills his remaining mobsters in an explosion, heading off to finish things on his own.

Phlegmming fires both Ozzy and Drix, but they keep investigating nonetheless, until they can be sure that Thrax is really gone. They go to the memory zone of the brain and discover that Thrax has sneaked in. Meanwhile, Leah Estrogen, the mayor's assistant and Ozzy's love interest, starts suspecting that something is amiss, but even when he can no longer ignore the situation, Phlegmming keeps underestimaing it. Leah starts her own investigation in the brain and stumbles upon Thrax, who stole a DNA bead from Frank's hypothalamus, causing his body temperature to skyrocket, and the entire city to be devastated in a fire, under Phlegmming's disbelieving and remorseful eyes. Despite her activating the alarm and putting up quite a fight, Thrax takes her as a hostage to force Ozzy and Drix, who caught up with them, to let him go.

Thrax battling Ozzy on Shane's eye

Ozzy battling Thrax in Shane's eye.

As Frank is being rushed into the hospital in critical condition, Thrax triggers a sneeze to exit his body, followed by Ozzy who used Drix's cannon to propel himself after his foe, landing in Frank's daughter Shane's eye. Ozzy and Thrax engage a fistfight, with Ozzy altering his body structure to avoid Thrax's deadly claw. Thrax strangles Ozzy with his DNA chain, gloating that he will break his record with Shane as soon as Frank dies, but Ozzie traps him on the girl's fake eyelash who is about to fall.

Ozzy clings to Shane's real eyelash, with the DNA chain still around his neck, while Thrax falls into a bottle of rubbing alcohol and dissolves to death. Ozzy then uses Shane's teardrop to re-enter Frank's body and replace the stolen DNA, saving Frank's live in extremis.

As Frank is saved and vows to adopt a healthier life-style, Phlegmming is impeached and Ozzy is appointed as an elite cop, with Drix as his partner and Leah as his girlfriend.


At first glance, Thrax appears to be collected, communicative, soft-spoken, suave and falsely polite, but it only serves to enhance the threat that he poses. To his core, he is very arrogant, boastful, brutal, violent, ambitious, completely remorseless and gleefully sadistic.

Thrax is notable for being a very dark and threatening villain in an otherwise lighthearted comedy. As a serial killer of the most heinous kind, he lives for the thrill of murder, which he regards as a challenge. He greatly enjoys causing death and suffering to people and cells alike, and he is also intensely proud of his killing-spree, often bragging about his many victims, among other displays of macabre dark humor. He always keeps a chain made of the DNA of all his victims as a creepy keepsake, and often singsongs Peggy Lee's "Fever" song when spreading his disease as a twisted sense of irony.

Thrax craves to attain infamy in medical books by breaking all records of deadliness. Whenever he enters the body of a new victim, he fixes himself a deadline to kill his target, each shorter than the previous. He has a volatile temper despite his often suave ways and often flies into short yet fiery rages at the prospect of obstacles. He prides himself in having never been spotted by his victims' organism before (until he entered Frank and Osmosis found out about him), and opposition only makes him more reckless and unhinged.

Despite his violent tendencies, Thrax has shown to be knowledgeable about human anatomy; knowing how to blend among common viruses, how to cover his tracks, and where to strike as efficiently as possible. Yet, his obsession about keeping his perfect record at all costs would lead to his downfall.


Thrax is a one-of-a-kind virus, characterized as a very tall and strong humanoid clad in black, with a long black coat that enables him to glide in the air, and a pair of dark shades he often wears. He has red skin, purple tentacle-like dreadlocks, yellow eyes, fangs, and clawed fingers, with a long claw on his index finger that can burn any cell it touches, be it living or material. His way of killing people is comparable to an extremely intense fever, raising the body heat until it can no longer bear it.


Ebola? Let me tell you something about Ebola, baby. Ebola IS A CASE OF DANDRUFF compared to me!
~ Thrax, being compared to Ebola.
Sounds like a gas, baby. Bring it on.
~ Thrax to The Boss.
This DNA bead came from a little girl in Riverside, California. Didn't like to wash her hands. Took me three whole weeks. And this one, nice woman in Detroit, Motown; Six days flat. Then there's this old guy in Philly. I killed him in 72 hours. Yeah, I'm getting better as I go along, baby, but the problem is I never set a record! Until my man Frank, that is. I'm gonna take him down in 48 hours! Get my own chapter in the medical books!
~ Thrax talking to a group of germ thugs, explaining his wicked evil plan to break his record by killing Frank Detore in 48 hours.
I said 48 hours, I'm gonna MAKE my deadline. Medical books aren't written about LOSERS!
~ Thrax killing his gang when they suggest laying low.
This cat was sick before I even got here.
~ Thrax after escaping from Frank's memories.
You know what, Jones? You want this chain so bad, Big Daddy Thrax is gonna let you have it! Looks good on ya, Jones! You wear it well! It's a shame you had to come this far from home just to die.
~ Thrax strangling Osmosis Jones with the chain.
Can you feel the heat, Jones? (laugh) Too bad you won't be here to see me break my record when I take down Frank's pretty little girl. (Ozzy: She ain't going down!) Huh? (Ozzy: YOU are!) WHAT?! NO!
~ Thrax's last words and Ozzy's response.


  • Thrax's name comes from the real life disease "Anthrax", though Thrax cannot be likened to any real-life virus. But, the symptoms resemble an exceptionally violent version of Scarlet Fever.
  • Thrax is described as La Muerta Roja (Red Death), in reference to the Edgar Allen Poe story, Masque of the Red Death; however the symptoms of the disease in the story bare little resemblance to the symptoms caused by Thrax.
  • The song that Thrax hums throughout the film is called "Fever".
  • Despite the film's failure at the box office, Thrax has been praised by most viewers.
  • He may be inspired the other Osmosis Jones villain, "Scarlet Fever".

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