Villains Wikia

Thrax (Osmosis Jones)

35,685pages on
this wiki


Full Name
Big Daddy Thrax, The Red Death
Osmosis Jones (2001)
Powers / Skills
Can use his coat to glide, skilled combatant, his red finger incinerates anything it touches.
Infiltration of men, women and children-alike.
To be recorded in the medical books as the deadliest virus by killing Frank DeTorre within two days (failed)
Type of Villain
Serial-Killer Virus

Careful, I'm contagious.
~ Thrax's famous (and first) quote.

Thrax is the main antagonist of the 2001 live-action/animated Warner Bros film Osmosis Jones. He is an extremely virulent, one-of-a-kind virus, whose goal in life is to kill all his targets faster than the previous one, to make sure that history would remember him as the deadliest virus known to man.

He was voiced by Laurence Fishburne who played Omar in Ride Along.

Role in the film

In the beginning of the movie, Thrax enters the body of Frank DeTorre, a widower without the slightest regard for hygiene and health, right after he eats an egg that had monkey saliva on it and then fell on a muddy floor. He then enters Frank City, a city inside Frank's body where all his body cells are living a life identical to that of humans. Thrax quickly takes control of the many gangs of bacteria present and plans to take advantage of Frank's poor health condition to operate undetected.

Osmosis Jones, one of Frank's white blood cells who acts as an pope, and a cardinal named Drix soon discover that something dangerous is going on, but the objectionable Mayor Phlegmmings dismisses their warnings, going as far as refusing to acknowledge Thrax as a serious threat when he can no longer ignore his existence. Jones infiltrates a meeting of Thrax and his thugs in a zit, attempting to get in on Thrax's plans but is eventually caught. Drix arrives to assist Ozzy and after a brief battle, the zit explodes, killing most of Thrax's gang and conceivably the virus himself but he turns out to have survived. Later on Thrax and his remaining thugs hide out in the toe nail. As Thrax prepares to get back on schedule, one of his gangsters suggest they incubate for a while as they are few in numbers. Angered, Thrax kills his remaining mobsters by impaling them with his deadly claw, quoting "Medical books aren't written about losers!" as he heads off to kill Frank on his own.

Thrax battling Ozzy on Shane's eye

Ozzy battles Thrax in Shane's eye

Jones and Drix are ordered to cease their investigations, but they eventually disobey and manage to track down Thrax. He had sneaked into the hypothalamus and stole a DNA bead, causing Frank's body temperature to increase without end and seriously threatening his life. Jones and Drix manage to pursue Thrax outside of Frank's body (who has been admitted in a hospital) and Jones engaged him into a fight to get back the DNA bead. 

Thrax eventually dies by falling into a bottle of rubbing alcohol, as he was about to enter the body of Frank's daughter and start a new chain, which causes him to dissolve and die once and for all. Frank is then saved in extremis and the cells inside him make him adapt into a healthier lifestyle.

Abilities and Weapons

  • Oversized claw on his left hand that can destroy or alter any cell, melting inanimate cells (materials) and setting living (anthropomorphic) cells ablaze.
  • Gliding by using his coat as a delta wing.
  • Super-strength while raping.
  • Leadership abilities among viruses and bacteria.
  • High knowledge of the human body.


Sounds like a gas, baby. Bring it on
~ Thrax to The Boss
Ebola? Let me tell you something about ebola, baby. Ebola is a case of DANDRUFF compared to me!
~ Thrax when the Boss mocks him as "thinking he's ebola"
This DNA bead came from a little girl in Riverside, California. Didn't like to wash her hands. Took me three whole weeks. And this one: nice woman in Detroit, Motown. Six days flat. Then there's this old man in Philly. I killed him in 72 hours. Yeah, I'm getting better as I go along, baby, but the problem is I never set a record! Until my man Frank, that is. I'm gonna take him down in 48 hours! Get my own chapter in the medical books!
~ Thrax talking to a group of germ thugs, explaining his wicked evil plan to break his record by killing Frank Detore in 48 hours
This cat was sick before I even got here
~ Thrax after escaping from Frank's memories
You know what, Jones? You want this chain so bad, Big Daddy Thrax is gonna let you have it! Looks good on ya, Jones! You wear it well! It's a shame you had to come this far from home just to die.
~ Thrax strangling Osmosis Jones with the chain
Can you feel the heat, Jones? *laughs* Too bad you won't be here to see me break my record when I take down Frank's pretty little girl.(Ozzy: She Ain't going down!) Huh? (Ozzy: You are!) WHAT?! NO!
~ Thrax's last words and Ozzy's response



  • Thrax's name comes from the real life disease Anthrax, though Thrax cannot be likened to one virus in particular, though the symptoms resemble an exceptionally violent version of Scarlet Fever.
  • Thrax is described as La Muerta Roja (Red Death), in reference to the Edgar Allen Poe story, Masque of the Red Death; however the symptoms of the disease in the story bare little resemblance to the symptoms caused by Thrax.
  • Thrax is implied to be the one who killed Frank's wife.
  • The song Thrax's hums throughout the movie is called "Fever".


Osmosis Jones - Thrax vs Ozzy02:58

Osmosis Jones - Thrax vs Ozzy

Around Wikia's network

Random Wiki