Prior to Kirito and Asuna's return to the Knights of the Blood, a twenty-member scouting party from five different guilds was preparing for the boss fight. When the first ten reached the center of the room, the entrance closed. The gate reopened five minutes later and neither the ten players nor the boss was seen. Like the previous boss, the battle area was also in an anti-crystal area, preventing the ten players from exiting the boss room.
The Skull Reaper is the most lethal of the Labyrinth bosses seen so far, easily claiming the lives of 14 players before being slain in battle. Despite being weaker than The Fatal Scythe, The Skull Reaper still inflicts large amounts of damage even with short combo attacks, being able to kill high-level players (the higher the level of a player, the more HP he or she has, making higher level players harder to kill despite their actual combat skills) with just one hit, and even forcing Asuna to assist Kirito in blocking its scythe arm (though Heathcliff could easily block the other one by himself, but he was using the system assist for it).
The Skull Reaper, befitting its centipede-like appearance, was able to move very quickly to outmaneuver the players, making it extremely difficult to avoid being hit by its attacks. Its huge and long body also makes it difficult to avoid the creature's strikes. The Skull Reaper also has an irregular targeting pattern (like most of the monsters on Floor 70+), as it ignored Heathcliff's shield after he blocked the attack in favor of killing the player he protected.
- The Skull Reaper is one of the 4 quarter (every 25 Floors) bosses in Aincrad. Like other such bosses, The Skull Reaper is much more powerful and dangerous than the bosses of adjacent Floors.
- The Skull Reaper is the first known boss in the Aincrad Arc with a known number of HP bars that has five health bars instead of four, suggesting that the bosses above it have a similar amount or higher.
- The arena of this boss surpasses the size of any other boss arena in the Aincrad Arc, as there is one large platform and multiple smaller platforms around the large platform.
- Although the attacks seem to be instant kills even for high-level players if it hits a player, it is most likely that this occurs when it hits a player in the torso or legs, as all the players that were shown to be killed by it were all hit in those areas. Agil was also hit by the tail, although he blocked it with his arm and did not die instantly, unlike the other two players who did.