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Hardly anything is known about the Lobe, except that he's an evil genius and proud of it, has a huge ego and despises Freakazoid for his stupidity. He is easily recognized by his short stature and huge brainy head. He has attempted to destroy Freakazoid many times. Like many villains, he also has two large bodyguards who assist him in some of his evil plans; such as kidnapping famed carpenter Norm Abram to force him to build an enormous wood-made weapon for him. At first, the Lobe planned to build it himself, but his inability with tools made him so angered that he ended up temporarily in an asylum. At the end, Freakazoid and Norm Abram join forces to defeat the Lobe. This episode also shows that the Lobe has a friendly relationship with all the other villains of the show, as he cheerfully invited them all to a big party once he believes Freakazoid is about to be destroyed.
Despite often bragging about his huge intellect, the Lobe has sometimes shown what appears to be a lack of self-confidence; this is especially evident in the episode "The Cloud" in which Freakazoid manages to defeat him just by pointing out how stupid his plan is, causing the Lobe to go away depressed and apologizing. After he's gone, Freakazoid admits to the audience that the plan was brilliant. Like all Freakazoid characters, the Lobe breaks the fourth wall quite frequently. In "The Island of Dr. Mystico" he expresses a strong desire to become the main character of the show, but wanders if he would be able to withstand the pressure.