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The Brain is a giant brain-like alien and the titular antagonist of the science-fiction horror film, The Brain.
Dr. Blakely runs a TV show called "Independent Thinkers", which is a Scientology-like self-help/religion program. But he's not making his audience think any more independently - with the help of an alien organism he calls The Brain, he's using brainwashing and mind control. The only thing that stands between them and world domination is a brilliant but troubled high school student with a penchant for pranks.