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Over the centuries, many people died trying to obtain the Arcanum, before it eventually fell into the hands of Kalina Oretzia. She and Cyrus Kriticos used the blueprints in the Arcanum to perfectly reconstruct Basileus's Machine, and to gather twelve of the thirteen spirits needed to power and activate the machine.
The Arcanum was most likely destroyed, either when it and Kalina were trapped between two closing glass walls in the machine, or otherwise, when the machine exploded.