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The Supreme Hunter is an antagonist of the video game Prototype.
The Supreme Hunter starts as a cancer weapon, a parasite that was created by Blackwatch to kill Alex Mercer. It started to kill him until Dr. Bradley Ragland cured him from it. Next, Alex attempted to inject the same parasite to Elizabeth Greene. Unfortunately, her body rejected it, and that's how the Supreme Hunter is formed. Alex manages to kill him, but he comes back to life when he steps on a puddle that is really him.
Sometime later, the Supreme Hunter caught Captain Cross, a normal soldier who is capable of taking Alex out, and absorbs him to get his form. Then he manipulates Alex into getting into a ship so that he can absorb him. However, that attempt failed when he, after revealing his true form, gets decapitated by Alex.