She was played by Rebecca Jenkins.
Sue Ann Grange was married to faith healer Roy Le Grange, who was once diagnosed with cancer and miraculously cured. Unbeknownst to Roy, Sue Ann used a reaper to cure Roy's cancer by taking the life of an innocent person, and continued to do so during Roy's healing sessions, with one occurrence happening while Roy was healing Dean Winchester. Dean and Sam figure out that a reaper was involved, but they originally figured that Roy was behind it all. It wasn't until they saved a protester of the sessions while a woman named Layla Roarke was called up that they realize that Sue Ann was the culprit, with Dean catching her with an ancient cross used to summon the reaper. Sue Ann's evil game plan was to kill people that she deemed were "wicked," and after she catches Sam in her attic, which has photos of people she has killed and a mark next to Dean, she locks Sam in. She sends the reaper after Dean, while Layla is again attempting to be healed of a brain tumor, but Sam escapes, removes Sue Ann's cross and destroys it. After this, the reaper goes after Sue Ann and kills her.