| "Spike" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.|
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- Spike (Lab Rats); An antagonist in Lab Rats and alternate personality of Chase Davenport.
- Spike (Buffy); A popular character from Buffy the Vampire Slayer, started off as a major villain but became an anti-hero later in the series.
- Spike (Mighty Max); An insane warrior from the Mighty Max cartoon series.
- Spike (Little Giants); A minor villain from Little Giants who later becomes a bigger treat.
- Spike (Sonic); A one-shot villain from the game Dr. Robotnik's Mean Bean Machine.
- Spike (Spyro); A minion of the Sorceress and a minor villain from Spyro: Year of the Dragon.
- Spike the Bulldog; A dog character from the Tom and Jerry cartoons.
- Spikes; Villain from Planet Hulk.
- Spike (Flushed Away); One of the secondary antagonists of Flushed Away.
- Spike (Land of the Lost); A villainous triceratops from the 1974 TV series Land of the Lost.
- Spike (Killer Klowns); One of the Killer Klowns from the 1988 film Killer Klowns from Outer Space.
- Spike (Heathcliff); A bulldog from Heathcliff.