Sleepwalker Patients are enemies appearing in Madness: Project Nexus. Their entire body is covered in bandages and they wear a distinct mask with wires and a red eyepiece. When a sleepwalker patient is killed, his mask will revive him. After being killed a third time, the mask will malfunction and explode, blowing up the sleepwalker patient. This can be avoided by decapitating a sleepwalker patient instead. This is also the case if a sleepwalker is killed by a Zombie or an Abomination.

Sleepwalker patients can wield and use weapons. They can also steal weapons and ammunition from the player.