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Before his mutation he was the governor of Siren Alley and Guardian of Sofia Lamb, Simon has a brother named Daniel Wales, both Simon and Daniel were the architects of the cathedral were working with Andrew Ryan to design the city, after the city was completed Simon and Daniel moved to Siren Alley to spread his religious view of the Rapture Family. After Ryan was killed by Jack, Simon was turned into a Spider Splicer, and tried to kill Delta but was killed by the big daddy.