Seth Voelker was born in Kenosha, Wisconsin. As Sidewinder, he was originally hired by the Roxxon Oil Company to retrieve the Serpent Crown, and outfitted with a cloak that had teleportation powers. Alongside the third incarnation of the Serpent Squad, Sidewinder was able to return the crown to company president Hugh Jones. However, after that stint, he decided to form his own criminal organization, the Serpent Society. Given his ability to teleport, Sidewinder promised his recruits they would never be imprisoned. This attracted several snake-themed villains, and the Serpent Society was quite the success. He also started a romantic relationship with his teammate Black Mamba.
Later, Sidewinder was betrayed by his organization after Viper infiltrated the group. After being poisoned, he was aided by Diamondback, who gave him the antidote, and the two escaped and survived. On being contacted by Black Mamba, Sidewinder repaid the favor when Diamondback was captured and sentenced to death by the Society and its new leader King Cobra, saving her from death by lethal injection. Sidewinder however refused to help Black Mamba and the Asp escape King Cobra's grasp, saying Black Mamba would not want to be in his debt.
A robotic Sidewinder later appeared and was employed by King Cobra.
Most recently, Sidewinder was seen in an interview and has since retired from villainy.
Gregory Bryan had been turned into the new Sidewinder by the Brand Corporation under the orders of Hugh Jones and was a member of the Serpent Society. After Gregory left, Cobra used the Brand Corporation's equipment (which had been long stolen by the Serpent Society) to create more Sidewinders.
Upon being improved, Sidewinder later sprung the other Serpent Society members from their cells. After the group had captured and chained Captain America and Diamondback (who was really an L.M.D.) in this underground New York headquarters, the pair escaped. Sidewinder was knocked out by "Diamondback". S.H.I.E.L.D. subsequently took Sidewinder and the rest of the Society into custody.
During the Secret Invasion storyline, Sidewinder re-joined the Serpent Society. The Society held a number of civilians hostage in a compound in the American Midwest claiming they were protecting themselves from the Skrulls. However, they were easily defeated by Nova and his new Nova Corps.