Did you think THAT was going to stop ME? ME?
~ Pride to Sam
I assume you're Lust
~ Dean to Lust
Only if you want me to be
~ Lust seduces Dean
We're not SINS, man, we're natural human INSTINCTS!
~ Envy to the Hunters

The Seven Deadly Sins are a blasphemous group of antagonistic demons that were the living embodiment of the seven cardinal sins. They served as the main antagonists of the Season Three premiere of Supernatural, "The Magnificent Seven".

The origins of these demons are unknown, though they themselves claim to merely be natural human instinct. The demons are as follows: Envy, Lust, Greed, Pride, Gluttony, Sloth, and Wrath. Their relations to one another is not elaborated on. However, they appear to be on amicable terms with each other, and to be protective of each other. When speaking to hunters, Envy referred to his companions only as "the others" and knew that they were coming to rescue him.

The Seven Deadly Sins have shown several rare powers. Most notably, they have the unique demonic power to influence humans by filling them with their individual sin by touch, and then, with a suggestion, compelling their victims to dangerous and usually deadly acts based on that sin. The demons have also been implied to be telepathic, being able to read a person's memories without possessing her, and one demonstrated the ability to incite moderately strong seismic activity to shake the house they were in and break a devil's trap on the ceiling. However, they have all standard demonic weaknesses.

The Seven Deadly Sins are last on Earth during the Dark Ages, about 500 years ago. In 1589, a man by the name of Peter Binsfeld becomes the first person to realize that the Seven Deadly Sins were not just vices but actual demons, and records this revelation accordingly. Around this time, the demons become trapped in Hell.

In May 2007, the Seven Deadly Sins are unleashed onto Earth once more when Jake Talley opens the Devil's Gate in Wyoming on Azazel's orders. Azazel means for them to serve as soldiers in a demon army led by Sam Winchester, known to the Seven Deadly Sins as "The Boy King"; however, after Azazel is suddenly killed by Dean Winchester, the Seven Deadly Sins disregard his plan and opt to enjoy their newfound freedom on Earth by inciting violent death among unsuspecting humans. A week later, they are found by hunters Sam, Dean, Bobby, Isaac, and Tamara, and a battle between both groups ensue; though the demons claim the life of Isaac, they are defeated, with Envy, Lust, Sloth, and Wrath getting exorcised back to Hell indefinitely by Tamara and Bobby, and Greed, Pride, and Gluttony getting killed by Ruby with her knife.