Senator Mendoza is a villain in the McBain series in The Simpsons. He is McBain's arch enemy.
He was a senator, however, he secretly ran a drug-cartel. McBain stumbled upon evidence that he was running the cartel, and thus attempted to bring Mendoza to justice. Mendoza also arranged for an assassination attempt on McBain at a diner via a planted "waiter," but Skowie, McBain's police partner and best friend, ended up taking the bullet. It is also revealed that Mendoza is the creator of a new drug substance called 'Swank', which he describes as ten times more addictive than marijuana.
Mendoza manages to plant a trap for McBain with a poisoned salmon puff and had his men to arrange an 'unfortunate accident' for the hero. However, McBain escapes and Mendoza eventually meets his end where McBain ends up killing the board of directors staff during a meeting, and then hurls Mendoza (who was attempting to sneak attack him with a pistol) out of the window onto a gasoline truck, being caught in the explosion.