In the game's first episode, she is first seen watching Scooby-Doo and his friends leave the Hambridge Library after they have foiled Walter Peabody.
In the game's fifth and final episode, she is finally re-seen when Scooby and his friends finally arrive at Shremantech Headquarters. Selena captures Fred Jones, Daphne Blake and Velma Dinkley and brainwashes them with their mind control device. Luckliy Scooby and his best friend Shaggy Rogers manage to destroyed the mind control device and get their friends back. Travis orders his henchman to seize Scooby and his friends, but they refuse and reveal themselves to Alan Dimmsdale (from the start of the game) and some federal agents. They try to arrest Travis and Selena but Selena escapes, arriving she reveals she was only playing along with Sherman's plan to further her own interests and intends to use the mind control device to rule the world. She then summons the Tome of Doom's most powerful ghost the fire king to kill Shaggy and Scooby. Luckily after Shaggy and Scooby defeat the game's last boss, Selena is arrested and her device is destroyed.
- Selena is the real main villain of the game because she had bigger plans than Travis.
- Selena's voice talent Grey Dieleise is also Daphne's current voice talent.