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Founded by the Leper Queen the Sapien League are one of the more extreme anti-mutant groups, their goals are to hunt down and kill as many mutants as possible - making them similiar to other murderous groups such as The Right and the Purifiers.
The Sapien League, like many anti-mutant organizations, are blinded by their hatred and prejudice into seeing mutants as a threat despite their murderous actions towards largely innocent mutant civilians.