The Sandman is the main villain of the Powerpuff Girls episode, "Dream Scheme". He is a magical being intends to get some sleep, but no matter what he does his clocks always tell him what town or country needs to sleep, so after Townsville's clock rings he builds a machine to put everybody to sleep forever, excluding the Powerpuff Girls, who have insomnia.
He visits the girls and then shoots a sand ray at them. The Girls give him a nightmare by fighting him in his dreams. He promises never again to sleep or hatch any schemes, and he wakes everyone up forever. However, the Girls go to bed anyway.