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The Rattlesnake is a villain in the videogame Deadly Creatures. Its goal is to kill the heroic spider.

The Rattlesnake first appeared when it ambushed the spider who exited out of the cave. The spider battles the Rattlesnake, dodging its attacks and tricked it into ramming into a cactus. The spider escaped while the Rattlesnake plotted to get revenge.

Th Rattlesnake later returns to get revenge on the spider. The Rattlesnake is defeated and met its end when George Struggs shoots the explosive barrels.