Queen Bee is often depicted as a member of an alien species that share similiar traits to some types of insects found on Earth - with her acting as the leader of the Hive, which function as a superorganism ruled over by her will.
Justice League Unlimited
In the show Justice League Unlimited she appears as a training hologram in the episode "Far From Home". She later joins the Legion of Doom.
Young JusticeQueen Bee is one of the major antagonist in the TV show Young Justice. She is one of the main members of the evil organization called The Light, under the alias of L-4.
DC Universe OnlineQueen Bee appears as a major antagonist in DC Universe Online where she allies with Brainiac against the heroes and villains of Earth - hoping to enslave them all in the process.
Blackhawk Squadron Villain
Queen Bee was the leader of an organization called "The Golden Swarm". They poisoned prominent townspeople and swayed public opinion in their favor partly by their comely appearance. The Blackhawks managed to defeat the Queen and her henchgirls by scaring them with mice.