Despite not causing nearly as much damage as he thniks the Professor Chaos persona has managed to get Butters into trouble, such as when he (in)famously got a shuriken to his eye playing a "game" with the other boys - where he had delusions of being a real supervillain (drawn in a classic "anime" style).
In a later episode, he joins the Legion of Doom. Professor Chaos has two minions, but in reality are just guinea pigs in tin foil. After a first grader named Dougie is similarly rejected by the boys, he bacomes Professor Chaos' right-hand man General Disarray. The two have hatched several half-baked ideas about how to take over the world, with one particular episode detailing how frustrated Professor Chaos gets when General Disarray tells him the The Simpsons have already done what he was about to do.
Professor Chaos would later become the archenemy of The Coon and Friends. The Coon would form a shaky truce with Professor Chaos in order to get rid of Mysterion and gain publicity, but Professor Chaos was disturbed at The Coon's plan to destroy a hospital and kill Mysterion. He would eventually be defeated by Mysterion and later on the entire team of The Coon and Friends. His last appearence was as their prisoner in Cartman's basement, where he was left to either starve or eat his own feces. The Coon also used Professor Chaos in his plan to frame Captain Hindsight.
- Professor Chaos may be based upon Magneto from X-Men, as he can create electromagnetic pulses similar to him, as seen in "Good Times with Weapons". He also has a similar helmet.
- His costume is a satire of the costume worn by Doctor Doom, a villain in the Fantastic Four comic book series.
- He was plagiarized in the British comic The Dandy, page 7 of issue 3565. A young reader had sent a picture of Professor Chaos in as a competition entry, part of the prize for which is the character appearing in a comic strip. He is depicted as an adult superhero, the artist apparently having failed to notice that Professor Chaos is an existing character.