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Principal Skinner at the left.

Principal Skinner at the left.

I'm going to enjoy devouring you, Bart Simpson. Yes. I'll believe I'll start as you've so often suggested, by eating your shorts.
~ Principal Skinner

Principal Skinner is the main antagonist of the Treehouse of Horror Segment Nightmare Cafertiria in The Simpsons. He began the story as being little more than his usual self but soon became a cannibal alongside the entire school-staff after getting a taste for human flesh, the cannibalism became so bad that soon teachers were sending children to "detention" regardless of them doing wrong and despite the mass number of children disappearing of Springfield (per usual) seemed oblivious to the dangers it faced. However Bart and Lisa were smart enough to realize what was going on, however by then it was almost too late and Skinner had effectively gained supreme power over the school (much more than even a Principal should have) and lost his sanity completely, starting with his shorts (no doubt about as revenge for Bart's famous taunt of "eat my shorts").

          The Simpsons Villains

Springfield Republican Party
Mr. Burns | Waylon Smithers | Blue-Haired Lawyer | Birch Barlow | Lindsey Naegle

Terwilliger Family
Robert Terwilliger Jr. | Cecil Terwilliger | Francesca Terwilliger | Gino Terwilliger | Robert Terwilliger Sr. | Dame Judith Underdunk

Springfield Mafia
Fat Tony | Fit Tony

Environmental Protection Agency
Russ Cargill

Miscellaneous
Itchy & Scratchy | Space Mutants | Patty & Selma Bouvier | Herman Hermann | Nelson Muntz | Jebidiah Springfield | Jimbo Jones | Dolph Starbeam | Kearney Zzyzwicz | Agnes Skinner | God | Jessica Lovejoy | Artie Ziff | Baby Gerald | Wainwright Montgomery Burns | Snake Jailbird | Senator Mendoza | Matt Groening | Constance Harm

Treehouse of Horror
Kang & Kodos | Killer Krusty Doll | Zombies | Ned Flanders | The Devil | Gremlin | Count Burns | Seymour Skinner | Lard Lad | Groundskeeper Willie | Hugo Simpson II | Bart (Fly) | Witch Marge | The Collector | Killer Toupée | King Snorky | Homer's Clones | Billy the Kid | Julius Hibbert | Jonathan Frink Sr. | Muttonchop Murderer | The Blob | The Grand Pumpkin

Guest Star Characters
Black Weasel | Cesar & Ugolín | Adil Hoxha | Lucille Botzcowski | Professor Werner Von Brawn | Bob Arnold | Lyle Lanley | Kindergarten Teacher | Adolf Hitler | Robotic Richard Simmons | The Leader | Movementarians | Francine Rhenquist | Hank Scorpio | Miss Goodthighs | Molloy | Rex Banner | Dexter Colt | The Jockeys | Hell's Satans | Jack Crowley | Cooder & Spud | French Chef | Jim Hope | Larry Kidkill | Howard K. Duff VIII | White Dog | Frank Grimes, Jr. | Captain Mordecai Barrows | Clownface | Simon Cowell | Officer Krackney | Shadow Knight | Baby Button Eyes | Stanley DeGroot | Will Wright | Stubborn Ape | Mr. Dirt | Sparklemon | William Shakespeare | Julia | Andy Hamilton | Devan & Quenley Woosterfield | Comic Book Guy (Brick Like Me) | Bart Simpson's Creatures | Mav & Portia | Blue-Eyed Man | Nigel Bakerbutcher