Dreyfuss was a director in the 1970s known for his controversial movies. In 1975 he tortured and killed Leonora Johnson. After this he wrote a confession letter to David Richards, stating that he had to kill her for artistic purposes. Richards tore up the letter and scattered them across Los Santos and Blaine County.
After all 50 pieces of the confession letter have been collected, Franklin Clinton visits Dreyfuss' house to confront him about the murder. Dreyfuss attempts to run away, and Franklin can either kill Dreyfuss or let him go. However, the in-game gold requirement to complete the mission requires him to be killed so his death is canonical.
He is voiced by Richard Hughes.