Paris Hilton is the main antagonist of the South Park episode "Stupid Spoiled Whore Video Playset".  

She opens a new designer store in the South Park mall, influencing all the girls (except Wendy) to emulate her clothing style and personality.  After her dog Tinkerbell commits suicide because being Paris Hilton's pet is unbearable, she decides she wants Butters as her new pet.  Butter's parents agree to sell him to Paris for $250 million, and after learning that all of her previous pets killed themselves, Butters panics and runs away.  Mr. Slave then challenges Paris to a "whore-off", which culminates in him shoving her up his ass.  As Mr. Slave encourages the girls' parents to make sure their daughters have better role models, Paris begins a "Lemmiwinks" style adventure.