George is a highly-strung professional photographer who is starting to unravel from the stress of his work with a Manhattan advertising agency. Needing some time away from the city, George, his wife Kim, and their son Miles head to upstate New York to take in the winter sights, though the drive up is hardly relaxing for any of them. George accidentally hits and severely injures a deer that ran onto the icy road. After George stops to inspect the damage, he's confronted by an angry local named Otis who flies into a rage, telling George that he and his fellow hunters had been tracking the deer for some time. An argument breaks out, which leaves George feeling deeply shaken.
Sure enough the next day while taking Miles sledding George is senselessly shot by Otis, leaving Miles alone and lost in the woods - frightened, Miles approaches his dad when he is chased by the wendigo and passes out. He is awakened later by a frightened Kim, who went looking for her family once they didn't come home. Kim and Miles begin a trek deep into the forest, until they end up at the house, where they find a bloody George crawling towards the car claiming Otis shot him.
Frantic, Kim and Miles put George in the car and drive to the nearest hospital. It is revealed that George and Miles were sledding near a shooting range and Otis shot George in the liver with a high powered hunting rifle.
George undergoes emergency surgery and Miles walks into the hospital, and hallucinates that his father is being assaulted by the Wendigo, faints and awakens only to find that George has died.
Otis is confronted by the local sheriff, but he kills the sheriff and drives away into the night, being stalked by the wendigo until he crashes into a tree and runs away into the forest, eventually ending up on a road where he is hit by the sheriff deputy's squad car. The movie ends with Otis being carted into the emergency room of the hospital, and being followed by the Indian shopkeeper while Miles watches it all, caressing the Wendigo figurine.