| "Omega" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.|
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- Omega (DC) - supervillain originally conceived as the embodiment of universal hate
- Omega (Doctor Who)
- Omega (Edge of Tomorrow)
- Omega (Final Fantasy)
- Omega (Gransazer)
- Omega (Lego) - the true main villain of the Lego movie The Adventures of Clutch Powers
- Omega (Mega Man Zero)
- Omega (Marvel)
- Omega Gang
- Omega Red - Soviet super-soldier turned supervillain
- Omega Tiger Woods
- E-123 Omega - a fictional robot from the Sonic the Hedgehog franchise.
- Kid Omega - traitorous former pupil of Xavier
- Kenny Omega, pro wrestler