Nuke (Frank Simpson) is a villain in the Marvel universe.
He was a test subject of the Weapon Plus program, the super-soldier program that had created Captain America and would later transform Wolverine into a killing machine. The enhancing and conditioning process went awry, leaving Nuke seriously deranged.
Later, he would do black ops for the American government. The Kingpin paid Nuke's handler to unleash Nuke on New York and to take out his enemies but Nuke was defeated and seemingly killed in battle with Daredevil and Captain America. He would eventually take up the mantle of the Scourge of the Underworld and join the Thunderbolts.