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The Nobodies are a powerful but dangerous group of twisted high-class demons, and enemies in Devil May Cry. These hideous 4-armed, masked beasts can change their size in battle to deal more damage, and being around them depletes the Devil Trigger gauge, making them even more difficult to kill. The moves and sound effects they make are very ape-like.
Nobodies are strange, large, "living toxins" that are without a true name. 'Jackels' of the underworld, they are despised even by Mundus and they were deemed unworthy ones. They look almost humanoid, but they often walk on all fours and have a grotesque arm growing out of their backs. Because they are tough opponents, Nobodies have unique abilities to go with their looks. They are able to perform a dance that drains away Dante's Devil Trigger gauge, knock opponents back with a devastating leap attack, and wear a mask that can increase their size. When becoming giant-like, each of these creatures are able to produce a packed "eyeball" full of the same toxin that the Nobody is composed of. They can throw this "eyeball", which will explode upon contact like a grenade, to damage far away foes. When they are killed, the Nobodies' bodies will begin to deteriorate and explode, damaging whoever stands too close to them.
- The Nobodies share the same name with the dark, empty creatures from the Kingdom Hearts universe.
- While the Enemy File provides an in-story explanation for the creatures' name, there is also a possible allusion to Homer's Odyssey. In the poem, when Odysseus and his crew are confronted with the Cyclops Polyphemus demanding to know his name, the Ithacan king tells him he is known as "Nobody". Later as part of Odysseus's escape plan, the crew blinds Polyphemus while passed out from excessive drinking in which he screams out to fellow neighboring cyclopes that "Friends, Nobody is murdering me by craft" who ignore him in indifference allowing Odysseus and his surviving crew members to escape to their ship and sail away.
- Thus in a sense when someone is encountering difficulty in fighting them, it is the Nobodies who has inflicted harm onto them. Though in an ironic reversal, the Nobodies in this game are most savage enemies who try to beat the protagonist (Dante) through brutish methods rather than mere cleverness.
- The Nobodies share similar traits in personality and movement with the psychopathic spirit known as The Jackal from Thir13en Ghosts.