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Menace is one of the many villains that have taken on the "Goblin" persona, first appearing in Amazing Spider-Man Vol.1 549.

History

Daughter of District Attorney William Hollister, socialite Lily Hollister was dating Harry Osborn. Her best friend was forensic specialist Carlie Cooper. One day, Lily found a hidden door in Harry Osborn's closet and found an old journal of his.

She uncovered the location of one of Norman's Osborn's secret rooms in the journal. When she had first gone in, she found all of the Goblin's equipment along with some experiments.

After accidentally knocking over some experimental Goblin chemicals, she absorbed them into her skin, and was now able to transform into her "Menace" form at will.

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Movies
Spider-Man: Norman Osborn/Green Goblin | Dennis Carradine | J. Jonah Jameson
Spider-Man 2: Otto Octavius/Doctor Octopus | Harry Osborn/New Goblin | J. Jonah Jameson
Spider-Man 3: Eddie Brock/Venom | Flint Marko/Sandman | Harry Osborn/New Goblin | J. Jonah Jameson
The Amazing Spider-Man: Curt Connors/Lizard | Gustav Fiers | Cash Register Thief | Norman Osborn
The Amazing Spider-Man 2: Max Dillon/Electro | Harry Osborn/Green Goblin | Donald Menken | Aleksei Sytsevich/Rhino | Alistair Smythe | Ashley Kafka | Felicity Jones
Spider-Man: Homecoming: Adrian Toomes/Vulture | Bestman Salvage (Phineas Mason/Tinkerer, Jackson Brice/Shocker #1, Herman Schultz/Shocker #2 & Randy Vale) | Mac Gargan | Aaron Davis
Venom: Eddie Brock/Venom | Carlton Drake/Riot | Roland Treece | Cletus Kasady