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Mega Mack is the semi-official name of the infamous pink "water" found in the Chemical Plant Zone in Sonic the Hedgehog 2.
Mega Mack was not poisonous in-game, however it was infamous for producing less air bubbles than normal water and thus made it much easier for Sonic to drown (a fact not helped by the general rule that Sonic can not swim).
In the United Kingdom's Sonic the Comic however Mega Mack was a more villainous tool in the sense it was deliberately created by Dr. Robotnik as a poisonous substance designed to eliminate Sonic - however an accident in the process of making this stuff resulted in the creation of the monster known as Megatox.