| "Medusa" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.|
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- Medusa (mythology) - The cursed snake-haired monster of Greek mythology.
- Medusa (DC) - The mythological enemy of Wonder Woman and a villainess in the DC comics.
- Medusa (Dungeons & Dragons) - A monstrous humanoid and a character
- Medusa (Dylan Dog) A creature in the comic book series Dylan Dog.
- Medusa (Disney) - A monster who has appeared as an enemy in Disney's Hercules (and most notably as a boss in the PlayStation videogame of the same name).
- Medusa (God of War) - mini-boss in God Of War (not to be confused with the similiar enemy-type known as Gorgons)
- Medusa (Kamen Rider X) - A monster villain in Kamen Rider X.
- Medusa (Kid Icarus) - The evil snake-haired goddess who is the main antagonist of the original Kid Icarus videogame and major antagonist in Kid Icarus: Uprising.
- Medusa (Marvel) - A former member of the Frightful Four and a character.
- Medusa (Rosario + Vampire) - The major antagonist in the Japanese manga Rosario + Vampire.
- Medusa (Wizard) - A major villain in Kamen Rider Wizard.
- Medusa Balls - Enemies from Dragon Warrior II.
- Medusa Gorgon - The major antagonist from the anime/manga series Soul Eater.
- Madame Medusa - The main antagonist of the Disney film Rescuers.