| "Medusa" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.|
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- Medusa (mythology) - The cursed snake-haired monster of Greek mythology.
- Medusa (God of War) - mini-boss in God Of War (not to be confused with the similiar enemy-type known as Gorgons)
- Medusa (Kamen Rider X) - A monster villain in Kamen Rider X.
- Medusa (Kid Icarus) - The evil snake-haired goddess who is the main antagonist of the original Kid Icarus videogame and major antagonist in Kid Icarus: Uprising.
- Medusa (Marvel) - A former member of the Frightful Four and a character.
- Medusa (Wizard) - A major villain in Kamen Rider Wizard.
- Medusa Gorgon - The major antagonist from the anime/manga series Soul Eater.
- Madame Medusa - The main antagonist of the Disney film Rescuers.