| "Margaret" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.|
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- Margaret (Marvel) - a leader of the Cult of 6G and a villainess from the Marvel comics.
- Margaret Holloway - a local judge from the town of Sheperd's Glen and an antagonist of SIlent Hill: Homecoming.
- Margaret Isobel Thoreaux -
- Margaret Moonlight - a scythe-wielding assassin and an antagonist from No More Heroes 2: Desperate Struggle.
- Margaret Morgan - the leader of the Lords of Salem and the main antagonist of Rob Zombie's Lords of Salem.
- Margaret Parangosky -
- Margaret White - Carrie White's mother and an antagonist from Stephen King novel Carrie.
- Madame Margaret - an antagonist from the Kids Next Door episode "Operation F.U.T.U.R.E.".
- Margaret Robinson - an character from The Amazing World of Gumball.