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The Many-Angled Ones are an alien threat found in the Marvel Universe, inspired by the works of H.P. Lovecraft - at first they were believed to be extra-dimensional demons belonging to a pantheon of Dark Gods but it was revealed that they were actually an entire universe populated by Eldritch Abominations who were the result of Death itself being removed from their reality, causing life to become cancerous and corrupt (as a result their reality is often refered to as the Cancerverse).
The Many-Angled Ones would proceed to try and infect the mainstream universe, causing many heroes, villains and cosmic entities to ally with one another to try and fight against the might of an entire parallel universe.