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Manda is a minor villain from Naruto and Orochimaru's personal snake summon. While Manda is loathe to serve anyone, he only serves Orochimaru because he apparently could not defeat him. Even so, he threatens to turn on his summoner when he shows any signs of weakness.
Manda is first seen in the Search for Tsunade arc. In the battle between the three Sannin (Tsunade and Jiraya vs Orochimaru, as well as Naruto and Shizune vs Kabuto), Manda is summoned to fend off the other two Sannins' respective summons, Gamabunta and Katsuyu. Kabuto fears that Manda will betray them and eat them both if he finds out that Orochimaru cannot perform hand signs, since his arms are still rendered useless after the battle with the Third Hokage. He takes pleasure in the possibility of devouring the other two summons and attacks. After failing to crush Katsuyu by constricting her, Jiraiya and Gamabunta attack with a jet of ignited oil, but Manda just sheds his skin and ambushes them. Tsunade wins the battle by stabbing a sword through Manda's mouth, pinning him to the ground. After proclaiming he won't be eating anything solid for about a month, he threatens Orochimaru and Kabuto before being unsummoned.
Manda is not seen again until after Sasuke's battle with Deidara. Just after Deidara blew himself up with his C0 in order to take Sasuke down with him, the latter summoned Manda. He put Manda under a genjutsu and used him to teleport safely away from the blast, costing the serpent his life. Suigetsu then summoned Manda to his location to save Sasuke, and because he disliked being used in such a way, the snake cursed Sasuke with his dying breath.
Kabuto later harvests Manda's DNA before the Fourth Shinobi World War, creating an even larger version of the serpent with arms. He uses the snake to hinder the turtle island where the jinchuriki had been hidden, but ultimately fails in capturing them.