Madame Mousey is the main antagonist of An American Tail: The Mystery of the Night Monster, the fourth and final sequel to the classic American Tail. She is a miniature french poodle who has started living among the mice about this time, appearing at every crime scene where the Night Monster, Twitch has struck, claiming to be a fortune teller. She is also the mastermind behind the night monster all along.

She is voiced by Candi Milo.


She faked being a soothsayer to get money from the mice. She created the Manhattan monster to get rid of the rodents because when she ran away from her owner, the other dogs didn't want to be around a dog who looks similar to a rodent. She snapped and got cats to help her make a monster to wipe away all the rodents of New York. She locked them in crates and sold them to cats to be eaten. In the end, Fievel knocks her out by using a live wire to shock her. At the end of the fight with the cats, Tiger and Tony catch Mousey from escaping into the sewer, and the dog council sends her back to her owner. She claimed it was even worse than going to the city pound.  

She despises Nellie for doubting the beliefs of the night monster and underestimating her. She gave Tony a fake clue to the night monster so Fievel and Nellie could go to an old house to be finished off.  



  • She is similar to Professor Ratigan from The Great Mouse Detective. They greatly hate being called a rat and lose their tempers when they are called one. However, unlike Ratigan, Madame Mousey has a bigger right since she is a french poodle, while Ratigan really is a rat.
  • She normally speaks with a french accent, but switches to a brooklyn accent when grumpy, hinting that the french one is false.
  • Her name is pronounced "Moo-say", despite its spelling.
  • A small running gag in the film is someone commenting on Mousey's size or that she looks like a rat and she starts growling, only to regain control a moment later.
  • If the American Tail series would have continued with more sequels, there is a small chance that Madame Mousey could have returned and get revenge on her mice enemies.


           Universal Animation Villains

Animated Features
Warren T. Rat | Mott Street Maulers (Digit) | Moe | Sharptooth | Cat R. Waul | Cactus Cat Gang (T.R. Chula, One-Eye & Sweet William) | Ozzy & Strut | Ichy and Dil | Pterano | Rinkus & Sierra | Dr. Victor Frankenstein | Steele | Niju | Nuk, Yak & Sumac | Mr. Grasping | Toplofty & O'Bloat | Scuttlebutt | Madame Mousey | Twitch | Danno Wolfe | Nightmare Train | Botticelli Remorso

           Don Bluth Villains

Animated Features
NIMH | Jenner | Warren T. Rat | Mott Street Maulers (Digit) | Moe | Sharptooth | Carface Carruthers | Killer | Hellhound | Grand Duke of Owls | Hunch | Frog Bouncers | Grundel Toad | Berkeley Beetle | Mr. Mole | Ms. Fieldmouse | Queen Gnorga | King Llort | Drake | Rasputin | Ludmilla | Drej Queen Susquehana | Drej | Preed | Joseph Korso

Cat R. Waul | Cactus Cat Gang (T.R. Chula, One-Eye & Sweet William) | Mr. Grasping | Toplofty & O'Bloat | Scuttlebutt | Madame Mousey | Twitch | Red | Belladonna | Martin Brisby | Dr. Valentine | Muriel & Floyd