Ma Mayhem had a husband whom she pulled numerous heists with. Her husband later left Ma for another woman, leaving their sons in her care. She pretends that her husband was dead but her sons remind her peculiarly. She was, at some point, sent to jail but escaped with her sons. Ma Mayhem later stole ruby jewels as they were the first swags that she stole with her husband. Mayhem and her sons broke into the Museum of Fashion when they fought Batman (Terry McGinnis). They later overcame Terry and fled the museum and carried Terry's Eggbaby in their truck. Terry used the Eggbaby to track down the criminal trio.
Batman faced Ma Mayhem again and saved the Eggbaby. Ma Mayhem tried to escape with the stolen rubies but was captured by Batman and sent back to jail.
Ma Mayhem is similiar to Ma Barker.