Lupe was a villainess in From Dusk Till Dawn 2: Texas Blood Money.
She was played by Maria Checa.
Lupe was a woman who Jésus encounters at the El Coyote motel, leading to a sexual tryst between the two. After the session, Lupe takes a shower, and it is that moment that she is attacked by a vampire bat (later revealed to be Luther Boggs, who had just became a vampire himself) and bitten several times. After Jésus fights with the vampiric Luther, Lupe rises as an evil vampiress and attacks Jésus. The fight results in Jésus smashing Lupe's head on the bathroom mirror, right before Jésus decapitates Lupe with a shard of glass from the mirror.