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The Los Santos Vagos are the overall tertiary antagonists throughout Grand Theft Auto: San Andreas.

Similiar to the Ballas, they are a group of Latino gang bangers who are the sworn enemies of the Varrios Los Aztecas and rivals of the Grove Street Gang. They control the far east and north of the city ever since their formation. When Carl Johnson returned to Los Santos, the Vagos were the second most powerful gang of the city behind the Ballas. The Vagos were also drug dealers and allied with the Rifa through drugs.