Loisette "Lois" Leffour is a witch who is one of the Grand High Witch's followers and is one of the main witches shown in the 1990 film The Witches (although she only has a minor role). She is one of the first witches the Grand High Witch meets in the movie.

Lois Leffour reveals she is from Southampton in England. Like all witches, her main hobby is murdering children, due to the fact they smell “like dog’s droppings” to her. When she goes to The Witches annual meeting at a hotel, she reveals what her true form looks like (She is bald and has scaly claws covered by gloves). When the Grand High Witches demonstrates how her new formula 86 turns Bruno into a mouse, Lois is shown cackling with delight.

When the witches smell out Lucas hiding in the room with them, Lois is one of the main witches to give chase. Lois meets her downfall with the other witches. Ironically they consume formula 86 after it was put in their soup by Lucas (who had been turned into a mouse).