She made her only appearance in the raid dungeon, Icecrown Citadel. There, she had succeeded Kel'Thuzad as the new leader of the Cult of the Damned after his demise in Naxxramas. In the Citadel, she rallied the cultists to defend the Lich King's lair. In a bloody battle the cultists were slain and Lady Deathwhisper joined the fray. After a long struggle, she was finally defeated and the entrance to the upper level of the Icecrown Citadel was opened.
- Lady Deathwhisper is the only female Lich to appear in the franchise.
- Because of the fact that she is a Lich, there is a possibility that she will return. Although, because she played a very minor role in the game, this may not happen.