Kuroh Sakamoto is the secondary antagonist in the game, Ninja Gaiden alongside his master, Kanbe Ogawa. He was also a teammate and rival of the game's protagonist, Ken Ogawa and a member of an elite ninja organization, GUIDE.

Kuroh is very skilled in Japanese martial arts, but he is irreverent and immodest. His overconfidence has helped him to grow and distinguish himself as the top fighter in the GUIDE team.


When the parasitic creatures called the Alpha Worms infected the citizens in Tokyo, Kanbe Ogawa and the GUIDE team arrive in the scene. After Kanbe leactured the ninjas, Kuroh was the first to go down into the city, followed by the others and lastly, Ken. The team soon got to work of destroying the mutants throughout Tokyo.