Living the early years of his boyhood in a malform-hating town called Humanity, Jono Hex's lower-class family was disliked by the affluant locals. Jono's father, a manure salesman, was a decent man who had been kicked in the head by a mule at an early age and tried hard to be accepted, but to no avail. Jono's mother died during the birth of his sister, who also died in the event after Humanity's doctors refused to help. Jono's father became a drunk as a result of his wife's premature death. Later, the children of Humanity set fire to the Hex house, destroying everything inside and killing Jono's father. During his escape from the burning building, Jono's malform (metamutant) power manifested itself, causing his lower jaw to be blown off and burning a gulch straight across his young face. Afterward, he was labeled as a malform and chased out of Humanity.
Jono grew up to be strong and mean, his foul temper became legendary and he founded the band of malform outlaws known as Generation Hex.
While robbing the mail train from Tombstone with the Seventh Cavalry's wages, Jono and Generation Hex were attacked by Marshal "Bat" Trask's mechanical Razormen. Jono and his band of outlaws retreated and rode non-stop for three days and three nights. After it became apparent that the Razormen would not rest until they destroyed a malform, Jono came up with a plan. The other members of Generation Hex returned to Jono's hometown of Humanity and terrorized its inhabitants for almost an hour. Concealing his scarred face, Jono rode into Humanity and pretended to chase the rest of Generation Hex out of town. The grateful people of humanity, who did not recognize Jono Hex, praised the tall, mysterious stranger as their saviour. They even asked him to be Humanity's sheriff, an offer which Jono declined. But before riding out of town, Jono instructed the citizens of humanity to disguise themselves as malforms so that they would be spared when the next band of malforms rode into town. Under jono's guidance, they used everything they could lay their hands on, anything that might disguise the fact that they were normal, decent, clean-living folk. Jono then rejoined Generation Hex and lured the Razormen into Humanity. the Razormen's primitive artificial intelligence scanned the disguised citizens of Humanity and concluded that they were malforms. Jono Hex stopped in the Boothill Graveyard just above town and looked back as the good folk of Humanity were massacred. He laughed all the way to Mexico.
Jono and Generation Hex battled Kultron, Will Magnus' robotic killing machine from the modern era. Unable to slaughter every metamutant in his era, Kultron traveled back in time to the Old West era to eliminate the malforms, the forefathers of metamutants.
- Jono Hex is based from DC's Jonah Hex and Marvel's Chamber.