In the episode, Lopez is portrayed as egocentric and possessed of an unstable temper, so, when a "younger" and "spicier" performer, also by the name of Jennifer Lopez, appears on the music scene, the executives of her record label are anxious to hire her. With this done, the label then fires the original Lopez, noting she is a "mean-spirited bitch, who spits on people for being poor". The dismissal and critique enrages Lopez, and, seeing that the new Lopez resides in South Park, travels there with boyfriend Ben Affleck to confront her replacement.
The original Lopez is naturally shocked and confused to find that the new Jennifer Lopez is in fact a hand puppet creation of Eric Cartman. She is enraged when the puppet insults her, and Lopez threatens to kill her and Cartman. Unbeknownst to her, however, Affleck is immediately attracted to the new Jennifer.The new Jennifer Lopez begins work on her album, and starts dating Affleck behind the original Lopez' back. Again enraged, the original Lopez proceeds to attack Cartman's hand with a baseball bat, breaking several fingers in the attack. This does not dissuade the puppet Lopez, and she continues to date Affleck, the two even becoming engaged. This sends Lopez over the edge, and she chases down the new Jennifer with a chainsaw, intent on killing her.
The police, record executives, Ben Affleck and Kyle, Kenny and Stan all chase after the two Lopezes (and by extension, Cartman), and are shocked to discover that the new Jennifer Lopez is, in fact, a con-artist named Mitch Conner, who commits suicide with a cyanide pill.
The original Lopez is arrested for assault and attempted murder, and after being released ends up working at a fast-food taco place.
Lopez is one of the few celebrities who does not appear in the episodes 200 and 201. Instead, Mitch Conner appears again, posing once more as Jennifer Lopez.