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Isis and Osiris are major antagonists in the book series The Secrets of the Immortal Nicholas Flamel by Michael Scott. They are the gods of ancient Egypt, who secretly act as the parents of the protagonists Josh and Sophie Newman. They are the masters of Dr. John Dee, the central antagonist of the series.
At first they only have minor appearances as Josh and Sophies parents and some as Isis and Osiris, but without any connections between their roles. They reveal their true identities not until the end of the fifth book.
In the seventh and last book, they act as the main antagonists, as they want to rule Danu Talis with the help of Josh and Sophie. However, after they turned against Isis and Osiris, they were defeated and killed in a short battle.